Sarcomatoid Mesothelioma

Mesothelioma is a cancer that attacks the lubricative layer lining the inside of the chest and abdomen and the internal organs. Pathologists categorize mesothelioma cancer cases according to levels of criteria, which are as follows: Location:

• Lungs (pleural mesothelioma)
• Abdomen (peritoneal mesothelioma)
• Heart (pericardial mesothelioma)

Stage:

• Stage 1 Mesothelioma - Cancer cells have started to form
• Stage 2 Mesothelioma - Cancer has spread locally
• Stage 3 Mesothelioma - Cancer has spread to adjoining areas
• Stage 4 Mesothelioma - Cancer has begun to metastasize

Cellular Structure:

• Epithelial (organized and structured)
• Sarcomatoid (random and irregular)
• Biphasic (a mix of epithelial and sarcomatoid)
• Desoplastic (a variation of the sarcomatoid variety)

Cellular structure is determined by an actual visual examination of the cells under a microscope.

About Sarcomatoid Mesothelioma

Sarcomatoid Mesothelioma accounts for approximately 10 to 15 percent of all diagnoses. The mesothelioma cell types in this case are elongated and spindle-shaped, and are arranged in a rather haphazard way. Sarcomatoid cells also lack a nucleus, unlike epithelioid cells, which have clearly visible nuclei.
The desoplastic variety of sarcomatoid mesothelioma is difficult to distinguish from healthy tissue in many cases, making an accurate mesothelioma diagnosis challenging.

Diagnosis

Once mesothelioma symptoms have been cataloged and a history of asbestos exposure determined, the next step is to look inside the body - initially with x-rays, followed up by more sophisticated imaging such as CT scans or MRIs. If these images reveal serious abnormalities, a biopsy (tissue samples) will be ordered. These are examined and analyzed at a lab, which usually confirms or contradicts the diagnosis.
When it comes to the sarcomatoid mesothelioma, traditional methods of biopsy pose additional challenges; the normal "needle core" method often results in false information, as sarcomatoid cells are often similar in appearance to benign fibrous tissue. Additionally, histological methods of diagnosis often make it difficult to distinguish between sarcomatoid mesothelioma and other types of unrelated sarcomatoid cancers.
A precise and accurate diagnosis is vital, because a misdiagnosis can lead to an inappropriate course of mesothelioma treatment being prescribed; it is a good idea to get a second and even a third opinion if mesothelioma is suspected.

Treatment Options

Although the details will differ depending on the individual case, all forms of cancer are treated through some combination of surgery, radiation therapy, and chemotherapy. How these are administered depends on the location and stage of the cancer.
Unfortunately, sarcomatoid mesothelioma is notoriously resistant to treatment, and the mesothelioma prognosis is not good. The average mesothelioma survival rate between diagnosis and death is seven months.

Source

Hammer, Samuel P. "Macroscopic, Histologic, Histochemical, Immunohistochemical, and Ultrastructural Features of Mesothelioma." Society of Ultrastructural Pathology Companion Meeting, 27 February 2005, http://sup.ultrakohl.com/Uscap/uscap05/meso1.pdf

Mesothelioma Law

Mesothelioma is an occupational disease caused by exposure to asbestos. Most of the individuals diagnosed with this rare form of cancer are those who worked with the toxic mineral at a variety of occupations including shipbuilding, construction work, welding, insulating, auto repair, oil refinery and chemical plant work, plumbing, and many more. They may have also been exposed at home through do-it-yourself projects. For decades before the U.S. halted all new uses of asbestos, scientists, doctors, and others knew it was toxic, yet it stayed on the market and companies continued to use it.
Though it's been more than 30 years since the government issued guidelines and warnings about asbestos use, the dangerous mineral can still be found in a high percentage of the homes and commercial buildings that were constructed prior to 1980, so exposure is still a real possibility. Furthermore, it sometimes takes up to 50 years after exposure for victims to be diagnosed with mesothelioma cancer because of the disease's long latency period. Hence, those exposed in the 60s and 70s can still be diagnosed with the disease in the near future.

Lawsuits and Compensation

It has been proven that, in many cases, owners or operators of plants, factories, or other businesses that made use of asbestos knew that the mineral was hazardous to the health of their employees yet no moves were taken to remove asbestos or to replace it with a safer material. Furthermore, those who manufactured asbestos-containing materials were also familiar with its hazardous qualities yet continued to make and market them. As a result, many individuals were wrongfully exposed to this toxic material and many were sickened as well.
During the last few decades, countless individuals who were injured by asbestos and developed mesothelioma have filed personal and class action suits against asbestos manufacturers and/or the owners of the companies responsible for their exposure in order to seek compensation. Treatment for this aggressive form of cancer is expensive and results in extensive medical bills and loss of income. Furthermore, victims of the disease have a right to be compensated for pain and suffering. In addition, they may wish to seek funds that will insure that their families will be secure after they pass away.

Asbestos Cancer and the Law

From the 1930s through the 1970s, tens of thousands of individuals, including union workers, were exposed to asbestos, mostly in the workplace. Those with jobs such as shipbuilder, construction worker, contractor, insulator, welder, oil refinery worker, chemical plant employee, railroad engineer, auto mechanic, and a host of other occupations were regularly exposed to asbestos on the job. As a result, many hardworking individuals developed serious asbestos diseases, including mesothelioma, a tough-to-fight cancer that continues to claim lives.
Those who worked with asbestos were rarely informed that the material was toxic and that their health was being compromised, despite the fact that executives at companies nationwide knew that hazardous asbestos was making their employees sick. Hence, no protection was provided and workers regularly breathed in dangerous asbestos fibers. Years later, many of these individuals would discover they had asbestosis - or worse - mesothelioma cancer.
The willing exposure of people to known toxins such as asbestos is, in the end, a matter of gross negligence. Employers who allowed exposure to this hazardous material were literally stealing the good health of their workers, resulting in the loss of quality of life for many individuals who would eventually be affected by mesothelioma. Furthermore, spouses, children, and other family members would also face the risk of acquiring mesothelioma through secondhand exposure. Those who grew up near asbestos plants or mines may have also suffered from exposure, not recognizing until years later that their close relationship with toxic asbestos would make them gravely ill.
If you or a loved one is suffering from an asbestos cancer such as malignant mesothelioma, you need the support and proven results of a firm like Early, Ludwick, Sweeney and Strauss. Skilled in presenting the facts, ELSS attorneys know the ins and outs of mesothelioma litigation and will strive to produce the kind of results that can help relieve the burden of a life with mesothelioma.
As with your mesothelioma treatment, time is also of essence when filing an asbestos-related lawsuit. Though laws vary from state to state, statutes of limitations may prohibit any legal action after a fixed period of time. Once an individual is diagnosed with mesothelioma, prompt action is required in order to stage a successful lawsuit against those who were responsible for your exposure to this hazardous mineral. Individuals considering filing a lawsuit should act quickly, increasing their chances for obtaining the compensation they deserve.

Mesothelioma Lawyer

In the fight against negligent asbestos exposure, the attorneys of Early, Ludwick, Sweeney & Strauss unite their strengths in asbestos litigation and worker's compensation to represent you and your family honestly and effectively.
With the assistance of our large network of asbestos specialists including physicians and other experts, our attorneys are capable of providing you with the most current information on asbestos and mesothelioma available to the public, assisting you in understanding your illness and acquiring the best treatment available. In addition, members of our well-versed legal staff can advise you on which legal options are available to you in order to preserve the financial security of you and your family, even after you have passed on.
Many law firms employ attorneys that handle thousands of cases annually and are unable to provide the adequate individual attention that each client needs and deserves, especially those dealing with the misery of a mesothelioma diagnosis. Conversely, Early, Ludwick, Sweeney and Strauss offers plenty of individual attention by assigning attorneys and paralegals to each client, ensuring that the client’s needs are always addressed in a personal and timely manner. Additionally, the firm has the ability to represent clients in any state, either directly or by way its extensive network of local attorneys who are situated throughout the country, so you can be sure that your lawyer is an expert in the laws of your locale.
Initial consultations at Early, Ludwick, Sweeney and Strauss are always free of charge and are designed to help us evaluate your case and measure your chance for a viable, successful lawsuit. In addition, because Early, Ludwick, Sweeney and Strauss operates on a contingency fee basis, the client pays nothing unless we succeed in your behalf and money is recovered.

Mesothelioma Symptoms

What are the warning signs of mesothelioma?

Mesothelioma is difficult to diagnose because the early signs and symptoms of the disease can be subtle at best. Symptoms are all too frequently ignored or dismissed by people who are inclined to attribute them to common every day ailments. Sometimes patients live with symptoms for up to 6 months before being diagnosed but usually the symptoms are present for two to three months prior to a mesothelioma diagnosis.

About 60% of patients diagnosed with pleural mesothelioma experience lower back pain or side chest pain and there are frequent reports of shortness of breath. Lower numbers of people may experience difficulty swallowing, or have a persistent cough, fever, weight loss or fatigue. Additional symptoms that some patients experience are muscle weakness, loss of sensory capability, coughing up blood, facial and arm swelling and hoarseness.

Peritoneal mesothelioma originates in the abdomen and as a result, symptoms often include abdominal pain, weight loss, nausea, and vomiting. In the event that there is a hernia present, fluid buildup may occur in the abdomen as well.

Anyone previously exposed to asbestos displaying any of these symptoms should seek medical attention from mesothelioma doctors who specialize in treating mesothelioma like Dr. David Sugarbaker.
How long does it take for mesothelioma symptoms to appear?

This is an excellent question. In fact, one of the most unique characteristics of mesothelioma is a long latency period that is very often associated with the disease. The latency period is the amount of time that elapses from the first point of asbestos exposure to the point where symptoms begin to appear so that a diagnosis can be made. In some mesothelioma cases the latency period is reported to be 10 years but the average latency for the majority of cases is between 35 and 40 years. As a result, the cancer often progresses to later stages before a diagnosis is made. When diagnosed in the later stages, mesothelioma treatment options become more limited and are less effective.

Mesothelioma Causes

What are the main causes of mesothelioma?

Mesothelioma is most predominantly caused by asbestos exposure. Asbestos fibers that are inhaled through the mouth and nose may eventually become embedded in the lining of the lungs, causing damage and resulting in mesothelioma lung cancer or asbestosis (scar tissue formation in the lungs). It has also been found that swallowing asbestos fibers could contribute to a form of mesothelioma originating in the abdomen called peritoneal mesothelioma.

Mesothelioma cancer generally results from occupational exposure but there are instances of environmental exposure to asbestos that can cause mesothelioma disease. Oftentimes second hand exposure of a family member to an asbestos workers dirty work clothes can result in that family member having a mesothelioma diagnosis.

Asbestos insulation workers appear to have the highest death rate. One study reports that almost six percent of asbestos workers fall victim to mesothelioma or experience mesothelioma symptoms and asbestos insulation workers are over 300 times more likely to die from mesothelioma than the general public.

Sources

Cancerbackup - Causes of mesothelioma
http://www.cancerbackup.org.uk/.../Causes
eMedicineHealth - Mesothelioma Causes
http://www.emedicinehealth.com/mesothelioma/page2_em.htm

Mesothelioma Cancer

Malignant mesothelioma is the most serious of all asbestos-related diseases. Although uncommon, mesothelioma cancer is no longer considered rare. Making a correct mesothelioma diagnosis is particularly difficult for doctors because the disease often presents with symptoms that mimic other common ailments. There is no known cure for mesothelioma, but treatments such as mesothelioma radiation and chemotherapy have helped to improve the typical mesothelioma prognosis.
Mesothelioma Cancer

The cavities within the body encompassing the chest, abdomen, and heart are surround by a membrane of cells known as the mesothelium. Mesothelial cells assist in general organ functions.

The mesothelium is particularly important to organs which are commonly in motion, such as expansion or contraction of the lungs, stomach, or heart. Lubrication from the mesothelial cells allows free range of motion within the body. The mesothelium of the chest, abdomen, and cardiac cavity are called the pleura, the peritoneum, and the pericardium, respectively. Each of these groupings of mesothelial cells are extremely critical to the functions of the body structures which they encompass.

Malignancies (cancerous tumors) occurring within the mesothelial membranes are known as malignant mesothelioma, or simply mesothelioma. Benign tumors of the mesothelium are known to occur, but are much rarer than the more common mesothelioma cancer.

While tumors of the mesothelium were first recognized in the late 18th century, it was not until the middle of the 20th century that this particular cancer was studied and examined with more detail. It was at this time where suspicions of the cancer’s causal relationship with asbestos exposure became more substantiated. A joint study through the Department of Thoracic Surgery at the University of the Witswaterand/Johannesburg General Hospital in South Africa provided the most compelling evidence of the nexus between asbestos exposure and the development of pleural mesothelioma.

Incidence of mesothelioma is still quite rare, with only 2,500-3000 diagnoses in the United States each year. There was a spike in reported diagnoses between 1970 and 1984, which has been attributed to the latency period between diagnosis and the height of industrial exposures- which occurred roughly 40-60 years prior to this time. Exposure was common in nearly all industries but was particularly common in the WWII-era military industrial cycle, including Navy Shipyards.

Although this cancer is much more common in men over the age of 60 (largely attributed to the industrial exposures within male-dominated industries), mesothelioma in women and children has been described as well. Mesothelioma causes for diagnosis in women and children are mainly attributed to secondary exposure to asbestos, as it was not uncommon for men to bring asbestos back into the home on their body or clothing if proper cleaning facilities were not available on site.

There are three recognized mesothelioma cell-types. Between 50 and 70% of all mesotheliomas are of the epithelial variety. While prognosis is generally poor, these are considered less aggressive than mesotheliomas of the sarcomatoid and biphasic variety, which comprise the remainder of diagnoses. Mesothelioma treatment options for each type of diagnosis are essentially the same, depending on stage at diagnosis and overall patient health.

Pleural mesothelioma (affecting the lung’s protective lining in the chest cavity) represents about three quarters of all mesothelioma incidence. Peritoneal and pericardial mesotheliomas, affecting the abdominal and cardiac cavities comprise the remainder. Testicular mesothelioma is extremely rare and is typically presents with metastases of the peritoneal variety.
How is Mesothelioma Cancer Treated?

Mesothelioma, while certainly an aggressive disease, is a treatable malignancy. While there is no cure for mesothelioma, treatment options including surgery, chemotherapy, and radiation therapy are available for many patients. While a combination of Alimta® and Cisplatin is currently the only FDA approved chemotherapy regimen, several clinical trials are currently in progress utilizing other drugs including Gemcitabine and Onconase, with many showing dramatically improved results in certain cancer patients.

Radiation therapy is also utilized, but typically in conjunction with other treatment methods like surgery and chemotherapy. Surgical resection of mesothelioma is possible in early-stage-diagnosed patients. Aggressive surgeries such as extrapleural pneumonectomy can extend survival rates far beyond previously-thought timeframes. Diagnostic and palliative surgeries such as pleurocentesis and pleurodesis are also common in patients of malignant mesothelioma cancer.

Alternative therapies have also been used effectively by many mesothelioma patients to assist in managing symptoms of the disease and conventional treatments. These treatments are mainly preferential but can be extremely valuable to many patients.
How is Mesothelioma Cancer Diagnosed?

Mesothelioma can be a difficult malignancy to diagnose because the symptoms and pathology of the disease closely resemble other respiratory conditions. For this reason, misdiagnosis is not uncommon in mesothelioma patients. Symptoms of mesothelioma include chest pain, chronic cough, effusions of the chest and abdomen, and the presence of blood in lung fluid.

Diagnostic surgeries, including a biopsy, will typically be required to determine the type of malignant cells that are present in the body. Typically a body imaging scan, including a magnetic resonance image (MRI) or computer topography (CT scan) will be required to determine the extent and location of the disease.

Mesothelioma patients are generally referred by their personal physicians to one of the many renowned mesothelioma doctors in the United States. These oncologists are well versed in the disease behavior and pathology and are the most familiar with cutting-edge mesothelioma treatment options. Dr. David Sugarbaker of the Brigham and Women's Hospital, an extension of Harvard University and the Dana Farber Cancer Institute in Boston, MA, is at the forefront of mesothelioma treatment through the International Mesothelioma Program.
What Causes Mesothelioma Cancer

Mesothelioma is known only to be caused by exposure to asbestos, though cases have been documented in children or other individuals with no asbestos history. Asbestos is a microscopic and naturally-occuring mineral that lodges in the pleural lining of the lungs and the peritoneal lining of the abdominal cavity. In most cases, several years will pass (up to 60) before mesothelioma develops in those who had been exposed to asbestos.

In many cases, those diagnosed with mesothelioma who are known to have been exposed to asbestos may be eligible for financial compensation from asbestos manufacturers for their illness. Those who have been diagnosed with mesothelioma and were exposed to asbestos should fill out the brief form on this page. We'll rush you a complimentary mesothelioma and asbestos exposure information kit detailing new mesothelioma treatments, active clinical trials, top doctors, as well as how to obtain compensation for asbestos-related health conditions like mesothelioma.